Tuesday, 25th July Symposium on Proteases and the Tumouri Microenvironment 2017

• Spatiotemporal modeling and live-cell imaging of proteolysis in the 3D tumor microenvironment - Bonnie F Sloane
• Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis   - Paul Timpson
• Three dimensional in vitro models for studying tumour angiogenesis - Laura J Bray
• A new tumour microenvironment: Emergence of intraductal carcinoma of the prostate in high risk cancer - Mitchell Lawrence
• Modulation of protease expression in prostate cancer cells after androgen targeted therapy: A focus on KLK14 - Thomas Kryza
• Invadolysin as a paradigm for modelling dynamics of the stromal microenvironment in Drosophila - Margarete Heck

Human rhomboid protease RHBDL2 regulates EGFR signalling in epithelial cells by the intramembrane cleavage of the EGF receptor - Nicholas A Johnson

Analysis of domain-specific interactions between Plasminogen and S100A10 - Blake Mazzitelli

Characterising the angiogenic potential of patient-derived stromal prostatic fibroblasts in a 3D in vitro model - Anthony Lighterness

The kallikrein-related peptidase 4 is involved in activation of prostate-derived stromal cells through the protease-activated receptor-1 - Thomas Kryza

Bioengineered microtissues enable analysis of the human prostatic tumour microenvironment in vitro - Brooke A Pereira

Significance of cathepsin B in gallbladder carcinogenesis - Siddharth Mehra

X-ray crystal structures of microplasmin in complex with sunflower trypsin inhibitor-1 (sfti-1) variants - Guojie Wu

Protease-controlled DARPin-toxin bioconjugates for tumor therapy - Hannes Merten

Stromal targeting of hyaluronic acid in patient-stratified models of pancreatic cancer - Claire Vennin

• Epigenetic hallmarks of the cancer microenvironment   - Susan J Clark
• Cysteine cathepsin trafficking comes of age – how to get around and beyond epithelial and carcinoma cells - Klaudia Brix
• Cancer associated fibroblasts in the prostate tumour microenvironment undergo chromatin alterations associated with aberrant gene expression - Ruth Pidsley
• Human rhomboid protease RHBDL2 regulates EGFR signalling in epithelial cells by the ectodomain shedding of the EGF receptor - Kvido Strisovsky
• The antitumoral glycoprotein CREG1 is regulated by lysosomal Cathepsin B - Alejandro Gomez Auli

Human rhomboid protease RHBDL2 regulates EGFR signalling in epithelial cells by the intramembrane cleavage of the EGF receptor - Nicholas A Johnson

Analysis of domain-specific interactions between Plasminogen and S100A10 - Blake Mazzitelli

Characterising the angiogenic potential of patient-derived stromal prostatic fibroblasts in a 3D in vitro model - Anthony Lighterness

The kallikrein-related peptidase 4 is involved in activation of prostate-derived stromal cells through the protease-activated receptor-1 - Thomas Kryza

Bioengineered microtissues enable analysis of the human prostatic tumour microenvironment in vitro - Brooke A Pereira

Significance of cathepsin B in gallbladder carcinogenesis - Siddharth Mehra

X-ray crystal structures of microplasmin in complex with sunflower trypsin inhibitor-1 (sfti-1) variants - Guojie Wu

Protease-controlled DARPin-toxin bioconjugates for tumor therapy - Hannes Merten

Stromal targeting of hyaluronic acid in patient-stratified models of pancreatic cancer - Claire Vennin

• Breast cancer protumorigenic vs antitumoregenic pleiotropy roles of MMP12 depend on tumor vs stroma origins - Chris Overall
• Differential proteomic profiling of non-malignant prostate fibroblasts and prostate cancer-associated fibroblasts (CAFs) identifies specific CAF-associated signalling networks - Roger J Daly
• Predicting extracellular matrix remodeling by tumor associated macrophages and breast cancer using systems biology of cathepsin proteolytic networks - Manu O Platt
• Quality systems in cancer research: Reducing irreproducibility - Ian Smith

Human rhomboid protease RHBDL2 regulates EGFR signalling in epithelial cells by the intramembrane cleavage of the EGF receptor - Nicholas A Johnson

Analysis of domain-specific interactions between Plasminogen and S100A10 - Blake Mazzitelli

Characterising the angiogenic potential of patient-derived stromal prostatic fibroblasts in a 3D in vitro model - Anthony Lighterness

The kallikrein-related peptidase 4 is involved in activation of prostate-derived stromal cells through the protease-activated receptor-1 - Thomas Kryza

Bioengineered microtissues enable analysis of the human prostatic tumour microenvironment in vitro - Brooke A Pereira

Significance of cathepsin B in gallbladder carcinogenesis - Siddharth Mehra

X-ray crystal structures of microplasmin in complex with sunflower trypsin inhibitor-1 (sfti-1) variants - Guojie Wu

Protease-controlled DARPin-toxin bioconjugates for tumor therapy - Hannes Merten

Stromal targeting of hyaluronic acid in patient-stratified models of pancreatic cancer - Claire Vennin

• TIMPless systems reveal new biology and signalling pathways - Rama Khokha
• Matrilysin activity and gene polymorphisms in the normal mucosa-adenoma-carcinoma sequence of colorectal cancer - Cornelis FM Sier
• Urokinase plasminogen activator receptor expression pattern and its prognostic implication for pancreatic cancer patients - Victor M. Baart
• Kallikrein-related peptidase 4 can initiate cleavage of the tumor-promoting receptor tyrosine kinase, EphB4, at the surface of prostate cancer cells - Adrian Herington
• The human kallikrein-related peptidase family: Clinical relevance of KLK mRNA expression in advanced high-grade serous ovarian cancer - Viktor Magdolen
• A multi-omics approach to determining the roles of the kallikrein-related peptidases in the tumour microenvironment - Judith Clements

The Conference Dinner will be held at Villa Medicea 'La Ferdinanda', a UNESCO World Heritage Site since 2013.
Please click here for more detailed information.

Cost: $95 per person

Address: Villa Medicea La Ferdinanda - Viale Papa Giovanni XXIII, 1 - 59015 Artimino - Carmignano - PO - Italia

Please note: A transfer from Monash University Prato Centre to Villa Medicea (and return) will be provided.

Dinner bookings can be made while registering for the conference or added at the later stage to your registration from the "Add-ons" menu.