Wednesday, 26th July Symposium on Proteases and the Tumouri Microenvironment 2017

• Understanding the molecular mechanisms underpinning cathepsin S expression in breast cancer - Chris Scott
• Mast cells cooperate with prostate cancer associated fibroblasts to drive tumour progression: A key role for mast cell tryptase - Stuart J Ellem
• Exploiting the immune cells and their proteases to degrade tumour ECM and improve drug delivery - Juliana Hamzah
• Fibroblast activation protein in glioblastoma microenvironment- possible pathophysiological role and new approaches of its therapeutic targeting - Petr Busek
• The response of glioblastoma cells to stromal cells is affected by cell- autonomous heterogeneity, affecting tumour cells invasion, which is mediated by proteases and bradykinin signaling - Tamara Lah Turnsek
• Significance of cathepsin B in gallbladder carcinogenesis - Siddharth Mehra
• Proteolytic homeostasis at intestinal epithelium surface: Implications for colorectal cancer - Nathalie Vergnolle

Human rhomboid protease RHBDL2 regulates EGFR signalling in epithelial cells by the intramembrane cleavage of the EGF receptor - Nicholas A Johnson

Analysis of domain-specific interactions between Plasminogen and S100A10 - Blake Mazzitelli

Characterising the angiogenic potential of patient-derived stromal prostatic fibroblasts in a 3D in vitro model - Anthony Lighterness

The kallikrein-related peptidase 4 is involved in activation of prostate-derived stromal cells through the protease-activated receptor-1 - Thomas Kryza

Bioengineered microtissues enable analysis of the human prostatic tumour microenvironment in vitro - Brooke A Pereira

Significance of cathepsin B in gallbladder carcinogenesis - Siddharth Mehra

X-ray crystal structures of microplasmin in complex with sunflower trypsin inhibitor-1 (sfti-1) variants - Guojie Wu

Protease-controlled DARPin-toxin bioconjugates for tumor therapy - Hannes Merten

Stromal targeting of hyaluronic acid in patient-stratified models of pancreatic cancer - Claire Vennin

• Indirect mechanisms of KLK4 inhibition: Opportunities for therapeutic intervention - Ashley Buckle
• X-ray crystal structures of microplasmin in complex with sunflower trypsin inhibitor-1 (sfti-1) variants - Guojie Wu
• Protease-controlled DARPin-toxin bioconjugates for tumor therapy - Hannes Merten
• Andecaliximab (GS-5745): A monoclonal antibody inhibitor of matrix metalloproteinase 9 - Andrew E. Greenstein
• Efficacy and safety of PD-L1 Probody therapeutics in murine models of cancer and autoimmunity - Olga Vasiljeva
• Proteases in growth factor signaling pathways in cancer - Robert Lazarus